Overexpression of miR-15b and/or miR-16 reduced TNFα and SOCS3 levels, while increasing insulin-like growth factor binding protein-3 (IGFBP-3) levels and the phosphorylation of insulin receptor (IR)Tyr1150/1151 in REC cultured in hyperglycemia. Here, SOCS3 is linked to Hyperglycemia.