The protein expression of PHLPP2 and FOXO1 were further found to be decreased in the bladder cancer tissues, compared with that of the normal bladder tissue, and miR-135a expression in these bladder cancer tissues was inversely correlated with the expression of PHLPP2 (r = −0.627, P < 0.05) and FOXO1 (r =-0.712, P < 0.05) (Figure 5B). Here, FOXO1 is linked to urinary bladder cancer.