To further confirm the importance effect of PHLPP2 or FOXO1 suppression during miR-135a-induced bladder cancer proliferation, a specific siRNA of PHLPP2 or FOXO1 was used to suppress endogenous PHLPP2 or FOXO1 expression, respectively (Figure 6A). This evidence concerns the gene PHLPP2 and urinary bladder carcinoma.