Since enforced overexpression of XIAP IRES enhanced XIAP expression as well as MDM2 stabilization that led to inhibition of p53, we selected both wt-p53 and p53-null cancer cells and treated them with siXIAP, in order to know whether both MDM2-p53 and XIAP signaling pathways are involved in the effect of XIAP IRES on cancer cell survival and apoptosis. The gene discussed is MDM2; the disease is cancer.