We used DSS to treat either the neuroblastoma cell line NB-1691 and LA1-55N, having endogenous MDM2 expression, or SK-N-SH having a transfected MDM2 to study MDM2 homodimerization and to evaluate whether homodimerization affects the level of MDM2 protein expression. This evidence concerns the gene MDM2 and neuroblastoma.