AQP4 and nervous system disorder: It is tempting to postulate that she had AQP4 antibodies at a level that was sufficient to cause abortion in her 2nd pregnancy and a relapsed rise of the antibody titre sufficient to cause a CNS syndrome in her 4th pregnancy given the known tendency of AQP4 antibodies to fluctuate and manifest during pregnancy and to precede neurological disease onset by as long as 16 years [13].