Considering the other experimental results in this study, including that MCPIP1 can be significantly induced by minocycline treatment in the brain, and that MCPIP1 has been identified as an important inducible anti-inflammatory regulator in stroke pathophysiology [11], it would appear more likely that MCPIP1 actually participates in the minocycline-treatment-induced neuroprotection. This evidence concerns the gene ZC3H12A and stroke disorder.