We have previously shown that (1) pigment epithelium-derived factor (PEDF), a glycoprotein with anti-oxidative, anti-inflammatory, and PPARγ-stimulating properties blocks the AGE- or IL-6-induced hepatic inflammation and (2) serum PEDF levels are independently associated with procollagen type III N-terminal peptide, a marker of hepatic fibrosis in patients with NAFL as a counter system against insulin resistance-related metabolic derangements [39-44]. The gene discussed is SERPINF1; the disease is Insulin resistance.