Moreover, consecutive analysis in 6 months intervals during 2 years in 19 patients with early-stage ADPKD (eGFR > 60 ml/min/1.73 m2) showed that urinary excretion of Fetuin-A increased progressively (p = 0.031, one-way ANOVA) (Figure 3b, Additional file 4: Figure S3a and Table 2). Here, AHSG is linked to autosomal dominant polycystic kidney disease.