Thus, the levels of snoRNAs are elevated in non-small-cell lung cancer (NSCLC), acute leukemias, and metastatic prostate cancer [54-56], and individual snoRNAs have been shown to contribute to cellular proliferation and/or transformation (SNORD114-1 in K562 cells [55], SNORA42 in breast cancer [57]). Here, SNORD114-1 is linked to breast cancer.