Importantly, Obermajer et al. [12] showed that MDSCs accumulate in the ascites of patients with advanced EOC, and that their purified CD11b+ myeloid cells suppressed T cell proliferation ex vivo. Furthermore, changes in the phenotype of tumor-infiltrating dendritic cells (DC) have also been shown to influence EOC progression in mice [13]. The gene discussed is ITGAM; the disease is neoplasm.