Immunoblotting showed that treatment with HDACi LBH589 and SAHA for 48 hours induced the degradation of mutant p53 in three LPS cell lines (LPS141/239, LPS141/266, and LPS510) and a mesothelioma cell line (JMN1B) (Figures 2 and 3A). This evidence concerns the gene TP53 and mesothelioma.