HDAC9 and mesothelioma: Cell proliferation was strongly inhibited in all LPS and mesothelioma cell lines in a dose-dependent manner after HDAC inhibition (Figure 3C): LBH589 and SAHA IC50 values in p53-mutant lines were 66 nM and 6.5 μM (LPS141/239), 110 nM and 7.1 μM (LPS141/266), 34 nM and 4.2 μM (LPS510), and 52 nM and 3.7 μM (JMN1B), respectively, and in wild-type p53 lines were 59 nM and 5.8 μM (LPS141), 41 nM and 4.2 μM (LPS778), 520 nM and 3.8 μM (MESO924), and 540 nM and 4.7 μM (MESO296), respectively.