Cell proliferation was strongly inhibited in all LPS and mesothelioma cell lines in a dose-dependent manner after HDAC inhibition (Figure 3C): LBH589 and SAHA IC50 values in p53-mutant lines were 66 nM and 6.5 μM (LPS141/239), 110 nM and 7.1 μM (LPS141/266), 34 nM and 4.2 μM (LPS510), and 52 nM and 3.7 μM (JMN1B), respectively, and in wild-type p53 lines were 59 nM and 5.8 μM (LPS141), 41 nM and 4.2 μM (LPS778), 520 nM and 3.8 μM (MESO924), and 540 nM and 4.7 μM (MESO296), respectively. Here, TP53 is linked to mesothelioma.