AKT1 and mesothelioma: Although the mechanism is unclear, we show here that HDACi LBH589 and SAHA induce PTEN expression in all LPS and mesothelioma cell lines tested (Figure 2 and Figure 3A) accompanied by AKT inhibition (Figure 3B), consistent with published data that NBM-HD-3, a potent HDAC inhibitor, increases PTEN expression [39].