In the present work, treatment with HDACi LBH589 and SAHA induced apoptosis and reduced cell viability in two p53 wild-type mesothelioma cell lines (MESO924 and MESO296) and one p53 mutant mesothelioma cell line (JMN1B), associated with an up-regulation of PTEN and p21, inactivation of AKT, and degradation of mutant p53 (Figure 3A–3F). This evidence concerns the gene TP53 and mesothelioma.