Additionally, Sbaa et al. [34] reported that EPC transduction with caveolin small interfering RNA, which mediates the endocytosis of CXCR4, regulating both the SDF-1-mediated mobilization and peripheral homing of EPCs to ischemia sites, leads to a more extensive rescue of the ischemic hind-limb. The gene discussed is CXCL12; the disease is ischemia.