NOS3 and ischemic stroke: However, Chen et al. [64] indicated that ACE2 could promote the migration of EPCs and tube formation, improve their function, and enhance the efficacy of EPC-based therapy for ischemic stroke based on the results from the in vivo and in vitro studies, which are mainly via regulating eNOS and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) pathways.