Cancer associated fibroblasts in the tumor stroma secrete pro-inflammatory cytokines such as Tumor Necrosis Factor-alpha and Interleukin-17 that can induce aerobic glycolysis in adjacent tumor cells via upregulation of transcription factors including HIF-1α, avian myelocytomatosis virus mammalian homolog, and Nuclear Factor Kappa B [13,14]. This evidence concerns the gene TNF and neoplasm.