However, objectification of immunologically mediated food hypersensitivity at the gastrointestinal level remains problematic, since atopy status is not a consistent feature in gastrointestinally mediated allergy (GMA), skin tests and allergen specific serum IgE detection may fail to show clear signs of food-specific sensitisation [1-5] and do not necessarily indicate symptomatic food allergy. This evidence concerns the gene IGHE and allergic disease.