TLR4 and ocular melanoma: For instance, polymorphisms in several components of the immune system, such as Toll-like receptor 4 (TLR4) [8], Mannose Binding Lectin [9], and pro-inflammatory cytokines such as TNF-alpha (tumor necrosis factor) and Interleukin-1 (IL-1) [10], have been reported to be associated with OM susceptibility, as well as polymorphisms in other genes that impair proper healing after a previous episode of OM [8].