The aim of this study was to study the clinical characteristics of peri-implantitis as established by the modified plaque index, modified gingival index and probe depth, examines the microbial and host response Interleukin (IL)-8, IL-1β, IL-6, IL-10 and Tumor Necrosis Factor (TNF)-α characteristics in dental implants with peri-implantitis, and establishes comparisons with healthy dental implants. This evidence concerns the gene TNF and Peri-Implantitis.