ADAM10, one member of the ADAM family, is involved in the shedding of dozens of substrates, such as CX3CL1, IL-6R, TNF-a and VE-cadherin, and this process plays a critical role in various inflammation-related diseases, including Alzheimer’s disease (AD), atherosclerotic cerebral infarction (ACI) and cancer [12-17]. The gene discussed is CDH5; the disease is Alzheimer disease.