Our results revealed that the ADAM10 rs653765 CC genotype carriers exhibited a significant increase in the expression of the three substrates of ADAM10 (CX3CL1, IL-6R and TNF-a) compared with the rs653765 CT/TT carriers in the subgroup of severe sepsis patients (Figure 3A-C) but that the expression levels of the pro-inflammatory cytokines IL-1β and IL-6 were not significantly associated with the rs653765 polymorphism (Figure 3D,E). The gene discussed is TNF; the disease is Sepsis.