ADAM10 and Sepsis: The novel findings from a secondary analysis were that the rs653765 C allele and CC genotype of rs653765 displayed a trend toward promoting the development of sepsis from the sepsis to severe sepsis subtype, and the CC genotype carriers was associated with higher ADAM10 mRNA expression in the severe sepsis subtype than in the sepsis (subtype) and further influenced the expression of ADAM10 substrates in the severe sepsis subtype, thereby potentially contributing to the progression from sepsis to severe sepsis.