Compared with the control group, the BLM and BLM + IL-27 antibody groups exhibited increased numbers of IL-4-producing CD4+ cells, IL-10-producing CD4+ cells and IL-17-producing CD4+ cells as well as a reduced number of IFN-γ − producing CD4+ cells and Foxp3-producing CD4+ cells. This evidence concerns the gene CD4 and Bloom syndrome.