Multivariate analysis demonstrated that IL-28B rs8099917 genotype TT is the strongest predictor for SVR (odds ratio [OR] = 13.422; 95% confidence interval [CI], 1.277 – 141.53; p < 0.031), followed by achieving RVR (OR = 6.853; 95% CI, 2.142 – 21.931; p = 0.001), male gender (OR = 4.813; 95% CI, 1.512 – 15.324; p = 0.008), absence of AF (OR = 4.403; 95% CI, 1.166 – 16.625; p = 0.029), and younger age (OR = 0.897 per 1 year increase; 95% CI, 0.83 – 0.969; p = 0.006). This evidence concerns the gene IFNL3 and atrial fibrillation.