INS and Hypoglycemia: Indeed, although most recommendations or guidelines have recently advocated for a higher glucose range target in the ICU based on recent meta-analyses showing a strong association between the glucose range targeted in insulin protocols and the risk for hypoglycemia, our study should lead to optimization of the quality of glycemic control by improving the algorithms embedded in glucose controllers that calculate insulin rates to avoid hypoglycemia, especially in situations where the patient is exposed to variable insulin resistance, rather than by simply increasing the blood glucose target.