In our study, we observed a high level of proinflammatory cytokines, such as TNF-α, IFN-γ and IL-12 in sera from SZU-101-treated tumour-bearing mice, while no induction of TH-2 cytokines IL-4, IL-5 or IL-10 was detected (Figure 1D). This evidence concerns the gene IL4 and neoplasm.