Ki-67 expression was used to assess the level of proliferation of shCTRL and shPODXL tumor cells, and we observed a significant increase in cell proliferation (increased number of Ki-67-stained cells) in shCTRL tumors compared with shPODXL tumors (Figure 2C, lower panel), showing that 37.6 ± 3.9% of shCTRL tumor cells were undergoing active proliferation, whereas no Ki-67-positive cells were detectable in shPODXL tumors. This evidence concerns the gene MKI67 and neoplasm.