PARP1 and hepatocellular carcinoma: Such a ROS-mediated cell necrosis was also found in human hepatocellular carcinoma SK-Hep1 cells treated with β-lapachone, where β-lapachone could induce cell necrosis through an activation of ROS mediated RIP1 /poly ADP-ribose polymerase 1 (PARP-1)/apoptosis inhibition factor (AIF) signaling pathway [6].