CXCL2 and Sepsis: Increased values for IL-1β, IL-6, IL-10 and CXCL-2 were also observed in all volatile anesthetic sepsis groups compared to isoflurane-sham animals (all P <0.03, Table 2), and IFN-γ was increased in isoflurane + CLP compared to isoflurane-sham animals (134.2 ± 131.9 versus 12.4 ± 12.2 pg/ml, P = 0.04; Table 2).