In case of abnormal laboratory tests [white blood cell count and C-reactive protein (CRP) at age 6–12 h] in well-appearing neonate with negative blood culture Polin and the Committee on Fetus and Newborn [11] (COFN) suggest to continue empiric antibiotic therapy if mother received antibiotics during labor and delivery in case of infants <37 weeks’ gestation with risk factors for sepsis and infants ≥ 37 weeks’ gestation born from mothers with chorioamnionitis. Here, CRP is linked to Sepsis.