In this regard the isolate MUL2216, that has been isolated from bronchoalveolar-lavage fluid (BAL) of a 43 year old male patient suffering from COPD and chronic, non-productive cough, is of particular interest, as it expresses five out of the nine nsSNPs classified as “vascular genotype” and contains only one tyrP copy. This evidence concerns the gene TYRP1 and chronic obstructive pulmonary disease.