In addition to mutations underlying the hemoglobinopathies, notably the sickle cell trait and the thalessemias, genes previously identified for severe malaria using the candidate gene approach include those involved in: cytoadherence of infected red blood cells to the endothelium (CD36), antigen recognition (HLA-B), antibody response (IL4) and the proinflammatory response (NOS2A) (reviewed in [4]). This evidence concerns the gene IL4 and malaria.