By comparing the top 15 methylation sites/islands associated with weight with the top 15 sites/islands associated with the obesity-related STK33 rs4929949 SNP, we found two CpG sites located near the promoter of CORO7: one CpG site displayed lower methylation levels in obese children and the other site displayed lower methylation levels in carriers of the rs4929949 risk allele. This evidence concerns the gene STK33 and obesity due to melanocortin 4 receptor deficiency.