In mice and patients with acute lung injury (ALI), the alveolar recruitment of Treg cells, specifically mediated by leukotriene B4 (LTB4)-leukotriene B4 Receptor (BLT1) pathway [10], contribute to the resolution of lung inflammation [7], particularly in the resolution of ALI fibroproliferation [9]. This evidence concerns the gene LTB4R and acute respiratory distress syndrome.