According to new nomenclature, M2/M1 GES, which should be named M(IL-4)/M(IFN-γ) GES, showed that M(IL-4) (M2 pro-tumourigenic macrophages) were more frequent in LIR (C2), which was characterized by a bad outcome, and that M(IFN-γ) (M1 tumour suppressor macrophages) were more frequent in HIR (C3), which was characterized by a favourable outcome. The gene discussed is IFNG; the disease is neoplasm.