The previous history of periodontitis has shown to influence the success rate in implant dentistry [2,32] and patients without history of chronic periodontitis present a higher average of implant survival in comparison with individuals with history of periodontitis.4 Our work supports the initial hypothesis that peri-implantitis and BRINP3 are associated and these results appear to be independent from the presence of chronic periodontitis, which suggests that if chronic periodontitis contributes to implant failure, it acts through a pathway not involving BRINP3. The gene discussed is BRINP3; the disease is Peri-Implantitis.