Notably, the World IBC Consortium reported an IBC-specific attenuation of tumor growth factor-beta (TGFβ) signaling and TCF4/TCF4 transcription factor activity, both of which are involved in the induction of EMT [3], and Chu et al. showed that reduced expression of E-cadherin promotes substantial reduction of the in vivo growth capability of primary tumors and metastasis in the SUM149 and MARY-X IBC models [21]. Here, TCF4 is linked to inflammatory breast carcinoma.