EGF and neoplasm: Furthermore, it has been reported that EGFR and EGFR phosphorylation promotes proliferation and invasion of IBC cells and is a relevant target in IBC [11,12], and that epidermal growth factor (EGF) secretion by the microenvironment’s tumor-associated macrophages is necessary to activate the invasive and metastatic potential of mammary epithelial cells [13].