Anaplastic Thyroid Carcinoma. In contrast, all hubs are DEGs and perhaps more outstanding, all of them are overexpressed: PLAU+, IL1B+, CCL20+, IL1RN+, MYD88+, IL8+, CD14+, TLR2+. The gene discussed is IL1RN; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.