Conditioned media from HGF-secreting fibroblasts and recombinant HGF treatment resulted in increased secretion of both urokinase-type plasminogen activator and its receptor (urokinase-type plasminogen activator receptor) by different ductal carcinoma in situ cell lines (MCF10.DCIS cells and SUM102 cells). The gene discussed is HGF; the disease is ductal breast carcinoma in situ.