MEFV and familial Mediterranean fever: Finally, in relation to the root of FMF without MEFV mutations, it is unclear, and there is a myriad of hypotheses, including misdiagnosis of other autoinflammatory disorders as FMF, epigenetic changes such as DNA methylation or hisotne modifications of MEFV, an interplay between genetic polymorphisms, modifier genes and environmental factors culminating in FMF spells, and mutations in yet unknown different genes causing a similar disease.