VCAM1 and Sepsis: During this shedding process, adhesion molecules are released and can be found in circulating blood; thus, in patients with sepsis, circulating levels of VCAM-1 and ICAM-1 parallel those of IL-6 [38]; this was more evident in patients with hyperglycemic sepsis, in which the inflammatory damage to endothelium may be worsened by persistent hyperglycemia [39].