IGFBP7 and Miyoshi myopathy: Analysis of proliferation by BrdU assay mirrored the viability assessment, showing weakly reduced proliferation of MM cells exposed to IGFBP7 (BrdU positive cells relative to control: 0.92 ± 0.04 and 0.69 ± 0.16 with 20 μg/ml rhIGFBP7 in OPM-2 and NCI-H929, respectively; P < 0.05) (Figure 4C).