The study has shown that that rs2273346 and rs6695096 of MASP-2 genes can increase susceptibility to TB, possibly because the mutation of rs2273346 (p.V377A) (TC, CC) and rs6695096 (TC, CC) can lead to decreased serum MASP-2 concentration and possibly decreased activity of MASP-2, and subsequently impairing the body immune function and increasing the risk of TB. Here, MASP2 is linked to tuberculosis.