NFKB1 and Hepatic fibrosis: The pro-fibrotic and pro-inflammatory roles of gp91phox are illustrated by the result of a previous study that demonstrated amelioration of hepatic fibrosis through knocking out gp91phox in mice [29,30] and that of another study showing inflammation through TNF receptor-1 expression and NFκB activation elicited by gp91phox induction [31].