IFNG and neoplasm: Interestingly, the lymphocytes from B16-F10-derived Ub-enriched proteins vaccinated mice produced a significantly higher level of IFN-γ than that from Ub-depleted proteins and whole tumor lysate vaccinated mice when stimulated with inactivated EL4 tumor cells (Figure 3C), similar results were observed when the lymphocytes from EL4-derived Ub-enriched proteins vaccinated mice were re-stimulated with inactivated B16-F10 tumor cells (Figure 3D).