Of these, Nr3c1 (Table 1), the gene coding for the glucocorticoid receptor (GR), was one of the highest-ranking MRs in several brain regions from which signatures were derived, including the central nucleus of the amygdala (CeA), medial prefrontal cortex (mPFC), and core sub-region of the nucleus accumbens (NAc), where it was recruited both in the context of non-dependent and dependent alcohol drinking; and the shell of the NAc and the ventral tegmental area (VTA), where Nr3c1/GR was recruited selectively by a history of alcohol dependence. Here, NR3C1 is linked to alcohol dependence.