However, clinical development of rhTPO for the treatment of chemotherapy-associated thrombocytopenia was discontinued due to the formation of neutralizing anti-TPO antibodies and subsequent development of thrombocytopenia associated with the use of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) [12]. The gene discussed is TPO; the disease is Thrombocytopenia.