In cases of DIC due to trauma, lower protein C and protein S levels, relative protein S deficiency, and impaired functions of both soluble and endothelial thrombomodulin are all implicated in the insufficient conversion of protein C to activated protein C and the inability of activated protein C. Therefore, increases in activated protein C levels do not indicate a shutoff of thrombin generation. This evidence concerns the gene PROS1 and hyperinsulinemic hypoglycemia, familial, 4.