Other abnormalities included deletion in PAX5 (a paired box transcription factor), and amplifications in MET, BRAF and aurora kinase A. The adenomatous polyposis coli (APC) gene responsible for familial adenomatous polyposis, was mutated in one patient; this gene, when aberrant, activates the Wnt signaling pathway and induces chromosomal instability [17,18]. Here, BRAF is linked to Familial adenomatous polyposis.