RUNX1 and acute myeloid leukemia: In additional support of the regulatory relationship between EVI1 and MS4A3, analysis of gene expression omnibus (GEO) microarray data sets GSE35159 [54], GSE6891 [57], GSE14471 [58], and GSE35784 [59] revealed that human myeloid cell lines and primary AML patient samples with high EVI1 mRNA levels exhibited low expression of MS4A3 and vice versa (Figure 1F, Table 1).