VWF and sickle cell disease: As such, vWF also represents a potential etiological factor throughout the myriad spectrum of vascular disorders, and has been implicated in thrombotic thrombocytopenic purpura clotting disorder, coronary heart disease [8], ischemia stroke [9], cerebral sinus and venous thrombosis [10], atrial fibrillation [11], hypertension [12], and sickle cell disease [13].