All of these changes would cause activation of TREK-2 channels and therefore, it has been hypothesized that TREK-2 in astrocytes may help maintain extracellular K+ and glutamate concentrations low during pathological events such as anoxia, ischemia, hypoxia, hypoglycemia and/or spreading depression [6,8]. The gene discussed is KCNK10; the disease is Hypoglycemia.