KIT and neoplasm: Based on the molecular pathogenesis of driver gain-of-function mutations in c-kit (80-90%) [1-4] and less frequently in the PDGFRα gene (5-10%), gastrointestinal stromal tumors (GIST) became a molecular model tumor in oncology emphasized by the central role of receptor tyrosine kinases in their molecular pathogenesis and the availability of small molecule inhibitor therapy.