Moreover, increased p-AKT and p-PTEN were observed in a time-dependent manner in IL-6-treated MM cells, but IL-6 did not interfere with the aloperine-mediated decreases in p-AKT and p-PTEN, indicating that aloperine reduces the cytoprotective effects of IL-6 on MM cells (Figure 4A). This evidence concerns the gene PTEN and Miyoshi myopathy.