This study showed that subjects with F scores ≤ 2.9 (corresponding to ≤ F1 status) and A scores ≤ 2.7 (corresponding to ≤ A1) had 100% of HB-complication-free survival after 4 years of follow-up, and that F scores outperformed combined classical predictors such as HBe antibody status, low AST activity, low viral load and absence of co-infections with HIV, HCV or HDV. The gene discussed is HBE1; the disease is coinfection.