Goede et al. [14] found that serum levels of Ang-2 in patients with metastatic colorectal cancer were significantly higher than in healthy individuals: moreover, in that study, compared with high serum Ang-2 levels, low serum Ang-2 was associated with an outstanding response rate, better disease control and excellent overall survival (OS). This evidence concerns the gene ANGPT2 and metastatic colorectal cancer.